Presidential elections to choose a permanent successor will be held within 90 days, Defence Minister Edgar Lungu said.
Mr Scott, who is of Scottish descent, becomes Africa’s first white head of state for many years.
Mr Sata died in the UK aged 77 after receiving treatment for an undisclosed illness.
He was being treated at London’s King Edward VII hospital where he died on Tuesday night.
‘Beloved comrade’
Mr Scott regularly stood in for the president at official events, but was never appointed acting president when Mr Sata was abroad – so this is his first time to officially lead the country.
In a brief televised address Mr Scott confirmed his appointment.
“The period of national mourning will start today. We will miss our beloved president and comrade,” Reuters news agency quotes him as saying.
| White leader appointed in Zambia |
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| White leader appointed in Zambia |
He is the second Zambian leader to die in office after Levy Mwanawasa in 2008.
Earlier this month reports in Zambia said that President Sata had gone abroad for a medical check-up amid persistent speculation that he was seriously ill.
He had rarely been seen in public since returning from the UN General Assembly last month, where he failed to make a scheduled speech.
After he left the country, Defence Minister Edgar Lungu was named as acting president.
Mr Scott is of Scottish descent and his parents were not born in Zambia, so he may not be able to run for president in January because of a constitutional clause. BBC
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